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FTD UK 2016 – the latest in FTD research across the UK

On 4th November 2016, researchers and clinicians from across the UK met at the 6th Annual FTD UK Meeting at Wolfson College at the University of Cambridge. The day was full of exciting updates about current and future research for both frontotemporal dementia (FTD) and overlapping conditions such as progressive supranuclear palsy (PSP) and motor […]

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2016 – the year ahead in FTD research

Recent years have seen huge steps forward in the FTD research field and as we enter 2016 this first FTD talk post of the year will summarize some of those areas. Therapeutic trials There are currently a number of small studies underway in FTD and we expect more to follow in 2016. One of the […]

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Distinguishing FTD from Alzheimer’s disease using brain imaging

Researchers in Sydney, Australia have been investigating an area deep in the brain called the striatum. Their work suggests that this area and the way it is connected to other areas of the brain could be used as a new marker to help work out whether someone has FTD or Alzheimer’s disease. We have a […]

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What causes people to develop the ‘phenocopy’ syndrome of FTD?

In a study published recently, Gossink and colleagues investigated the link between psychiatric and psychological factors in people who develop a disorder which has been termed the behavioural variant FTD ‘phenocopy’ syndrome, and identified a variety of psychiatric and psychosocial factors which may contribute to the manifestation of this condition. What is the bvFTD phenocopy […]

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The First World FTD Awareness Week

Today is the first day of the first World FTD Awareness Week. FTD talk has been up and running now for just over one year and during this time we have been trying to increase awareness for frontotemporal dementia and associated conditions. We hope that the factsheets and information on the website are helpful for […]

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How common is FTD in Asia?

Frontotemporal dementia (FTD), the second most common cause of dementia under the age of 65 in many Western cohorts after Alzheimer’s disease (AD), appears to be relatively less common in Asian populations. It often ranks third or even fourth, behind AD, vascular dementia and Parkinson’s disease dementia respectively. With regards to familial FTD, the proportion […]

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World FTD Awareness Week

This week we have a guest post from Jill Walton who runs the UK FTD Support Group to let us know about the first ever week to raise awareness about FTD. Jill writes: As a result of our collaboration with FTD support groups from around the world at the International FTD Conference in Vancouver last […]

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Psychosis is more common than previously thought in frontotemporal dementia

FTD is a progressive condition so multiple aspects of cognition, function and behaviour may eventually become affected, and psychiatric states like apathy, depression, anxiety, irritability, agitation and aggression are not uncommon. In contrast, the set of symptoms known as psychosis appeared to be rare until recently. Psychosis in dementia Psychosis consists of hallucinations and delusions […]

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GENFI – the first published results of the multicentre Genetic FTD Initiative

Approximately one third of patients with frontotemporal dementia have their disease caused by a problem in one of their genes, with these mutations most commonly involving the genes progranulin, microtubule-associated protein tau, or chromosome 9 open reading frame 72 . For many years research has focused on patients once they have developed symptoms, however recently […]

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Small but dangerous? Protein cleavage products linked to FTD

Genetic alterations in the progranulin gene (PGRN) have been known to cause FTD since 2006. The mutations act by reducing the production of the progranulin protein by half, but little is known about the biological processes linking loss of progranulin to neuronal death. A new study by Salazar and colleagues suggests it may not be […]

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The tau protein in FTD: results from a post-mortem study of 373 individuals

The tau protein is important in the normal function of the brain. It is associated with structures within brain cells called microtubules which help one cell to speak to another cell. In its normal state tau helps to stabilize microtubules but when tau clumps together in the abnormal state, microtubules are destabilized leading to death […]

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Is oxytocin a means for restoring social behaviour in FTD?

Oxytocin, a brain peptide, promotes positive social behaviour in humans and other mammals. It promotes maternal behaviours, and its administration facilitates responsiveness to social cues and co-operative behavior in healthy adults and individuals suffering autism – a developmental disorder featuring handicaps in socialization and communication. It is plausible oxytocin will improve social behaviour in FTD, […]