The key challenge my research aims to address stems from the large variability we see in patients with the behavioural variant of frontotemporal dementia (bvFTD). This is both in terms of the type of abnormal proteins actually driving the disease process, as well as which symptoms and brain regions are predominantly affected. I am using MRI scans to measure patterns of changes in the brain and symptom questionnaires in a large group of patients to help classify and better understand these different subgroups within bvFTD. I am also using these imaging and symptomatic markers in patients who have been studied over several years to improve our understanding of how the disease progresses over time. An additional aim is to use these brain and behaviour profiles to improve our ability to predict which pathological proteins are causing the disease process in life. This is important to improve enrolment of patients into the correct clinical trials when new treatments for these abnormal proteins become available.