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Small but dangerous? Protein cleavage products linked to FTD

Genetic alterations in the progranulin gene (PGRN) have been known to cause FTD since 2006. The mutations act by reducing the production of the progranulin protein by half, but little is known about the biological processes linking loss of progranulin to neuronal death. A new study by Salazar and colleagues suggests it may not be […]

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The tau protein in FTD: results from a post-mortem study of 373 individuals

The tau protein is important in the normal function of the brain. It is associated with structures within brain cells called microtubules which help one cell to speak to another cell. In its normal state tau helps to stabilize microtubules but when tau clumps together in the abnormal state, microtubules are destabilized leading to death […]

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Is oxytocin a means for restoring social behaviour in FTD?

Oxytocin, a brain peptide, promotes positive social behaviour in humans and other mammals. It promotes maternal behaviours, and its administration facilitates responsiveness to social cues and co-operative behavior in healthy adults and individuals suffering autism – a developmental disorder featuring handicaps in socialization and communication. It is plausible oxytocin will improve social behaviour in FTD, […]