Jargon free research updates for the whole frontotemporal dementia community

Kinesin_cartoon

The tau protein in FTD: results from a post-mortem study of 373 individuals

The tau protein is important in the normal function of the brain. It is associated with structures within brain cells called microtubules which help one cell to speak to another cell. In its normal state tau helps to stabilize microtubules but when tau clumps together in the abnormal state, microtubules are destabilized leading to death […]

Hypothalamus_image

Is oxytocin a means for restoring social behaviour in FTD?

Oxytocin, a brain peptide, promotes positive social behaviour in humans and other mammals. It promotes maternal behaviours, and its administration facilitates responsiveness to social cues and co-operative behavior in healthy adults and individuals suffering autism – a developmental disorder featuring handicaps in socialization and communication. It is plausible oxytocin will improve social behaviour in FTD, […]

Tau_PSP

The first anti-tau drug trial: davunetide is not an effective treatment for progressive supranuclear palsy

Progressive supranuclear palsy (PSP) is a neurodegenerative disease that causes slowed and stiff movements, frequent falls and difficulty with voluntary eye movement. Clumps of the protein called tau are found in the brain cells of patients with PSP. Tau protein is important for stabilizing microtubules, which comprise the cell’s skeleton and are involved in transporting […]