Jargon free research updates for the whole frontotemporal dementia community


GENFI – the first published results of the multicentre Genetic FTD Initiative

Approximately one third of patients with frontotemporal dementia have their disease caused by a problem in one of their genes, with these mutations most commonly involving the genes progranulin, microtubule-associated protein tau, or chromosome 9 open reading frame 72 . For many years research has focused on patients once they have developed symptoms, however recently […]


Small but dangerous? Protein cleavage products linked to FTD

Genetic alterations in the progranulin gene (PGRN) have been known to cause FTD since 2006. The mutations act by reducing the production of the progranulin protein by half, but little is known about the biological processes linking loss of progranulin to neuronal death. A new study by Salazar and colleagues suggests it may not be […]


The tau protein in FTD: results from a post-mortem study of 373 individuals

The tau protein is important in the normal function of the brain. It is associated with structures within brain cells called microtubules which help one cell to speak to another cell. In its normal state tau helps to stabilize microtubules but when tau clumps together in the abnormal state, microtubules are destabilized leading to death […]