Biomarkers

Fluid Biomarkers

Our fluid biomarker team are embedded in the UK Dementia Research Institute Biomarker Lab at UCL run by Henrik Zetterberg and Amanda Heslegrave. We also collaborate with the Mass Spectrometry Lab at the UCL Institute of Child Health run by Kevin Mills. We have recently written a review of fluid biomarkers in FTD, highlighting our work so far and our plans for the future.

Ongoing projects include:

  • Measurement of markers of neurodegeneration and astrocytosis in FTD
  • Understanding the role of neuroinflammation in FTD
  • Development of novel biomarkers of tau and TDP-43 pathology
  • Validation of assays to measure progranulin
  • Investigation of lysosomal dysfunction in FTD
  • Development of a hypothalamic peptide panel
  • Urinary biomarkers in FTD

Team Members